Abstract
A 40-year-old woman, who had a history of obesity from 20 years of age, was diagnosed with type 2 diabetes at 28 years of age. At 30 years of age, she was started on insulin therapy for strict metabolic control before pregnancy. Despite increasing the maximum dose of metformin up to 2,250 mg and a total insulin dose of 100 U/day (1.07 U/kg/day), her glycemic control remained unstable with a HbA1c value of 9.8 % and a fourth admission to our hospital. She was treated with diet and exercise therapy and administered 50 mg of ipragliflozin from the third to 13th hospital day. At discharge from the hospital, her total insulin dose was decreased to 53 U/day (0.60 U/kg/day). She lost weight, her BMI decreased from 38.7 kg/m2 to 36.3 kg/m2, the area of visceral fat decreased from 365.6 cm2 to 246.9 cm2 and the visceral/subcutaneous fat ratio decreased from 0.88 to 0.66 after a 10-day short-term administration of ipragliflozin. An analysis of the body composition report indicated that the weight loss was nearly entirely due to body fat loss. We herein report a successful case of a patient who was able to become pregnant after the short-term administration of ipragliflozin and the observed improvement of her metabolic abnormality through select indices.
