Journal of the Japan Diabetes Society
Online ISSN : 1881-588X
Print ISSN : 0021-437X
ISSN-L : 0021-437X
Case Reports
A Case of Type 2 Diabetes Mellitus With Miliary Tuberculosis Confirmed by Liver and Bone Marrow Biopsies After Initial Quinolone Therapy
Keiko OdaToshifumi GushimaKazuhiro TakahashiKazuhiko Kogawa
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2015 Volume 58 Issue 12 Pages 902-907

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Abstract
A 71-year-old woman with type 2 diabetes mellitus and hypertension was admitted to our hospital due to physical immobility, a fever and hyperglycemia. No typical finding of miliary tuberculosis was observed on chest computed tomography on this admission. She was first diagnosed with a biliary tract infection according to an elevated C-reactive protein concentration, a liver enzyme test and wall thickening of the gall bladder on abdominal computed tomography and ultrasound, and antibiotics were administered. During two weeks of antibiotic therapy, the C-reactive protein level decreased by quinolone antibiotic therapy, however, her fever and liver dysfunction persisted. A liver and bone marrow biopsy showed Langhans giant cell and epithelioid granuloma without caseous necrosis and miliary tuberculosis was consequently suspected. When she developed acute lung injury on day 22, anti-tuberculous therapy was initiated and her general status and liver dysfunction thereafter rapidly improved.
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© 2015 Japan Diabetes Society
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