Abstract
We compared the clinical outcomes of Japanese diabetic patients above 20 years of age with type 1 (T1DM) or type 2 (T2DM) disease (age of onset under 20 years) using data obtained from 36 institutes participating in the Japan Diabetes Clinical Data Management Study Group. Compared to the patients with T1DM (586 patients, age: 30.8±0.4 years at the final visit), the patients with T2DM (385 patients, age: 34.8±0.8 years at the final visit) had higher BMI, systolic blood pressure and non-HDL-cholesterol values and a greater frequency of treatment discontinuation. The two groups showed the same HbA1c levels at the final visit (T1DM: 8.2±0.1 %, T2DM: 8.1±0.1 %) and a similar prevalence of microangiopathy. In the cross-sectional analysis, the HbA1c levels in the T1DM patients gradually decreased in association with the duration of diabetes (9.0±0.2 % at 5 years, 8.2±0.1 % at 20 years), whereas the HbA1c levels in the T2DM patients increased (8.4±0.2 % at 5 years, 8.9±0.4 % at 20 years). Although the prevalence of retinopathy increased similarly in association with the diabetes duration in the patients with T1DM and T2DM, that of nephropathy increased more in the patients with T2DM than in those with T1DM.
