2016 Volume 59 Issue 8 Pages 569-575
This study investigated the urinary liver-type fatty acid-binding protein (urinary L-FABP) levels and nephropathy in 695 patients with type 2 diabetes. Abnormal urinary L-FABP levels were detected in 9.9 % of the patients, which was lower than the percentage of patients with abnormal albuminuria levels (24.6 %). We found that the patients in the abnormal urinary L-FABP group showed a low eGFR and a high level of albuminuria. The eGFR decreased and urinary L-FABP increased with an increase in the albuminuria level. We compared the patients with normal and abnormal levels of urinary L-FABP in combination with normoalbuminuria, microalbuminuria, and macroalbuminuria. The group of patients with abnormal urinary L-FABP and microalbuminuria group showed a lower eGFR than the normal urinary L-FABP and microalbuminuria group. Among the patients with microalbuminuria, those with an abnormal level of urinary L-FABP showed a lower eGFR. We suspect that the renal function was decreased by the increased number of complicated kidney lesions in the group of patients with abnormal levels of urinary L-FABP and microalbuminuria.
