A Case of Anti-GAD Antibody-positive Fulminant Type 1 Diabetes with an HLA Haplotype that is Rare for Japanese

Abstract

A 66-year-old woman was admitted to our hospital with diabetic ketoacidosis of remarkably acute onset. Her plasma glucose concentration was 719 mg/dL, her HbA1c level was 5.9 %, and her urine C-peptide level was undetectable. Based on the diagnostic criteria for fulminant type 1 diabetes (FT1D), the patient was diagnosed with FT1D. The patient was positive for anti-GAD antibody. She possesses an HLA DR-DQ haplotype, which is very rare for Japanese.