Clinical Background Associated with Decreased Urinary Uric Acid Excretion in Japanese Patients with Type 2 Diabetes

Abstract

Hyperuricemia involves not only overproduction of uric acid but also its decreased excretion. The urinary uric acid-to-creatinine ratio (UUA/UCr) was measured in 470 Japanese patients with type 2 diabetes as a method of evaluating urinary uric acid excretion, and the factors associated with urinary uric acid excretion were investigated. The UUA/UCr was 0.46±0.18, and the patient background characteristics associated with a decreased UUA/UCr were male sex, a reduced estimated glomerular filtration rate, and the use of urate synthesis inhibitors. The UUA/UCr was significantly lower in the group with hyperuricemia and no use of urate synthesis inhibitors (0.44±0.16) and the group with hyperuricemia and use of urate synthesis inhibitors (0.28±0.13) than in the group with normouricemia (0.51±0.17). Patients with a UUA/UCr of <0.5 were significantly more frequent in the group with hyperuricemia and no use of urate synthesis inhibitors (69 %) and the group with hyperuricemia and use of urate synthesis inhibitors (94 %) than in the group with normouricemia (51 %). It is therefore necessary to consider the new prescription of urate-lowering drugs in male subjects or patients under the use of urate synthesis inhibitors with type 2 diabetes.