Abstract
Elucidation of the effect of diabetic agents on thlipid metabolism would appear important io considering the prophylactics against vascular complications which are the main causes of daeth in diabetics.
Accordingly, the author investigated the effects of an oral diabetic agent, butyl-biguanide (BBG) on lipid metabolism in diabetics and rats with diabetes.
The following results were obtained:
1) BBG caused no significant changes in the levels of blood sugar and plasma free fatty acid (FFA) for three hours after the administration of the agent.
2) Chronic administration of BBG, however, decreased plasma FFA and normalized the composition of fatty acids and alsp ameliorated the disturbed pictures of plasma triglycericie and cholesterol.
3) Adipose tissue uptake of FFA in vitro was not affected by addition of usual dosage of BBG both normal and alloxari diabetic rats, while it was restored to normal in adipose tissue of diabetic rat treated with BBG chronically.
These findings suggest that the attainment of BBG effect on lipid metabolism requires a certain period of time and its effect is exerted through the process of enzyme synthesis, etc.
