Abstract
Thirty eight pregnant women with glycosuria (first trimester 9, second trimester 17 and last trimester 12) were infused intravenously 300ml of 10% 1-arginine for the purpose of studing the diabetogenic factor factor during pregnancy.
The levels of serum HGH, blood sugar, serum IRI and NEFA were determined and the rusults were compared with those of 11 puerperal women and 10 normal nonpregnant women.
The fasting serum HGH level of pregnants was higher in the second and last trimester compared with normal nonpregnant level, but it was similar to nonpregnant, if the value of cross reaction of human chorionic somatomammotropin (HCS) 3 mugml was deducted from HGH level.
The HGH response in the first and last trimester was same as that of control, but in the second trimester, it wasl ower.
The low response in the second trimester had no significant difference from those in another trimester and control.
The HGH response in puerperal women was much lower thanthose in pregnant and control women. The level of blood sugar was similar in pregnancy and puerperium, but lower than control. Serum IRI response in the second trimester was lower than control and another group, and the fasting value of NEFA increased gradually with the advance of pregnancy.
These results suggest that the secretion of HGH does not have much responsibility for the diabetogenic effects during pregnancy, and the mutual effects of HGH and HGS should be clarified.
