Abstract
The influences of free fatty acids (F.F.A.) on the uptake of glucose into muscle, adipose and liver tissues of rats were studied in vitro.
The extents of the influences were affected by the kind of the tissues, and the concentrations of glucose and administered F.F.A. in the medium.
When the F.F.A. concentration was equivalent to the normal plasma level of rats, suppression of glucose uptake into the muscle and liver tissues was observed under a condition where 200mg/dl of glucose existed in the medium. Under the same condition, glucose uptake was accelerated in the adipose tissue. When the administered F.F.A. concentrations increased, glucose uptake in the three tissues accelerated.
When a normal plasma level of F.F.A. was administered, suppression of glucose uptake into the muscle and adipose tissues and an output of glucose from the liver tissue were observed under a condition where 100mg/dl of glucose existed in the medum. When the administered F.F.A. concentration increased, suppression of glucose uptake into the muscle and adipose tissues was observed. In the liver tissue, the degree of the output of glucose from the tissue decreased.
When the administered F.F.A. increased, the triglyceride content of the liver tissue significantly increased under a condition where 200mg/dl of glucose existed in the medium.
The influences of the essential fatty acids such as linoleic and arachidonic acids on the glucose uptake were different from those of the other fatty acids.
