Abstract
A 49-year-old male, who had been known as a diabetic since 1966, was admitted to the Saiseika Kanakawaken Hospital on April 12, 1972, due to a mild fever and abdominal distension. On admission, he was noted to have bronchitis, chronic nephritis and liver damage, and he suddenly died of hematemesis on the 64th Lospital day. Autopsy revealed arteriosclerosis and hemorrhagic gastritis, and microscopical examination discicsed multiple necrotic foci and cryptococcus neoformans scattered diffusely in the lungs, liver, kidneys, spleen and pancreas. Most of the Langerhans' islets were damaged with the necrotic foci, although only a few foci were seen in the exocrine pancreas. Hyperglycemia of the patient was mild and was controlled with only dietary treatment.
The diabetes of the patient was thought to be associated with the damages in the islets caused by the cryptococcal infection.
