Abstract
Increases of glucose excretion were observed in urine after 2 hours of a 40 g D-galactose tolerance test. At that time no more significant increase of blood glucose concentration was observed than in the control groups. Therefore, urinary glucose excretion after galactose loading was increased without the elevation of blood glucose levels. On the other hand some significant relationships were found between urinary glucose excretion and the elevation of blood galactose levels during galactose tolerance tests. Furthermore, the summation of stereoisomers, blood glucose, and galactose concentrations seemed to affect urinary glucose excretion and blood glucose threshold levels as a whole.
The monosaccharide transports in the kidney have been reported to be related to the stereospecificity of molecular structures. Following the interaction between glucose and galactose, galactose was absorped through the membrane in preference to glucose, and then glucose was excreted in urine. These findings suggest the necessity of chemical and steric studies on renal glycosuria.
