Abstract
The relationships between serum triglyceride level (TG) and other metabolic derangements of 606 Japanese adults were examined with multiple regression analysis (stepwise forward selecting method) by computer system.
All of those 606 subjects were divided into three subgroups according to insulinogenic index (II) and to degree of glucose intolerance. The relationships between TG level and other metabolic derangements, such as basal insulin level (IRI), percentages to ideal body weight for scaling of obesity, and fasting blood sugar level (FBS) were examined in three subgroups as follows;(A) 98 subjects with lower-II (II<0.4) of normal glucose tolerance, (B) 196 subjects with hyper-II (II≥0.8) of normal glucose tolerance, and (C) 69 subjects with lower-II (II<0.4) of abnorma glucose tolerance.
In order to help explain the mechanism leading to the metabolic abnormalities of hyper-TG, hyper-IRI, and hyper-FBS, stepwise forward selecting regression analysis was carried out with computer, and its results suggested that the Mechanism of carbohydrate and lipid metabolism are quite different in above three groups. The subjects of group (A) have little possibilityof becoming hyper-FBS, but, those of (B) possibly become hyper-IRI and hyper-FBS when they become obese, and those of (C) were considered to be in insulin insensitivity because of hyper-IRI and hyper-FBS in spite of normal weight.
More striking findings were that the increase in fasting serum triglyceride level possibly could be a parameter of insulin insensitivity.
