Abstract
An association has been demonstrated between the HLA antigens and Bw 15 and juvenile dibetes mellitus in Caucasians. However HLA-B 8 is almost absent in the Japanese. For this reason, a racial point, HLA typing was performed by a lymphocytotoxicity micromethod on 60 insulin-dependent diabetes mellitus patients who had developed diabetes mellitus by the age of 15 years, and on 355 healthy controls.
27 HLA antigens were tested with 100 selected antisera.
In these patients, we observed an increased incidence of HLA-BW 22.1: 25.0 per cent in patients as against 5.6 per cent in controls, HLA-BW 22.2: 23.3 per cent in patients 4.5 per cent in controls. This difference is highly significant.
