Lipid Peroxide in the Plasma of Diabetics

Abstract

The lipid peroxide in the plasma of 103 diabetic patients and 331 control subjects was measured by a fluorometric method using thiobarbituric acid.
1) The plasma lipid peroxide values of diabetics (5.48 ±0.76 nmole/ml) were significantly (P<0.001) higher than those of controls (3.74 ±0.13 nmole/ml).
2) The plasma lipid peroxide levels were higher (P<0.001) in poorly controlled diabetics (6.39±1. 21 nmole/ml) than those in well controlled diabetics (4.08 ±0.38 nmole/ml). However, no significant correlation between plasma lipid peroxide values and glucose tolerance was found.
3) The plasma lipid peroxide levels had no relation with hypertriglyceridemia and hypercholesterolemia.
4) The plasma lipid peroxide values were significantly (P<0.001) higher in diabetics with angiopathy (7.69 ± 1.65 nmole/ml) than those without angiopathy (3.89 ±0.55 nmole/ml).
The above results suggest that lipid peroxide plays an important role in the occurrence and progression of angiopathy in diabetics.