Abstract
A patient who had shown generalized allergic skin reactions to conventional insulin was desensitized by Monocomponent Insulin injections. At the first stage, this diabetic could not receive conventional insulin treatment due to allergic reactions. After Monocomponent Insulin had been increased to the largest dose without any such reactions, conversion of treatment from Monocomponent to conventional insulin induced urticaria. Such skin reactions continued even after readministration of Monocomponent Insulin. Decreasing the dose of insulin was then attempted, and under this clinical course, the urticaria disappeared and good control of the patient's diabetes mellitus was established.
Serum insulin binding antibody (IgG) increased gradually during the course of desensitization.The Prausnitz-Küstner test and skin reactions to insulin were positive even after desensitization. On the basis of these findings, it is suggested that antibodies belonging to IgG might be blocking antibodies. However, before the increase of IgG antibody was found in the patient's serum, desensitization was almost completed. This suggests the possible existence of another mechanism ofdesensitization, such as neutralisation of sensitizing antibody.
