Studies on CH_5O in Juvenile-onset Diabetics with Insulin-dependency

Abstract

Titers of CH_5O were assayed in 30 JOD (juvenile-onset diabetics with insulin-dependency) and 4 MODY (maturity-onset diabetics among young people).
In patients with a JOD history of less than 3 years, the CH_5O titer was significantly lower than that in patients with a history of more than 5 years. The CH_5O titer in JOD patients with a duration of from 5 to 10 years did not differ significantly from that in JOD patients with a history of more than 10 years. The CH_5O titer in patients with a JOD history of less than 5 years was significantly lower than that in MODY patients, who had an almost identical duration.
These results suggest involvement of the complement system in the earlier phase of JOD.