Abstract
The changes of HbAt and red-cell 2, 3 DPG on 100 g OGTT were studied in 9 diabetics and 10 non-diabetic control subjects.
The results obtained were as follows:
(1) The HbAi levels in the 9 diabetics increased gradually after glucose ingestion. The average level reached its highest point at 180 min, and there was a significant increase between the level before glucose ingestion and that after 180 min, based on the student pair t-test (p<0.01).
These findings suggested that HbAi was produced by the hyperglycemia for glucose load, and that fast glycosylation of HbAi is partially effected during 100 g OGTT.
(2) In the case of the diabetics, the serum inorganic phosphate concentrations after glucose ingestion decreased a little and at the same time the red-cell 2, 3 DPG levels increased in 7 of the 9 diabetics, but not significantly. In the non-diabetic control subjects, the average level of serum inorganic phosphate after glucose load reached its lowest point at 60 min and returned to the original level at 180 min. In this group, the redcell 2, 3 DPG levels decreased significantly on glucose load, both at 30 min and at 60 min. (p<0.05).
It can be hypothesized therefore that, because the IRI responses increased after glucose load, the serum inorganic phosphate decreased and led to a relative decrease of red-cell 2, 3 DPG concentration in the controls. On the other hand, such phenomena did not occur in the diabetics.
