Abstract
Serum LCAT activity was measured in 82 diabetics and 50 non-diabetic controls in order to examine the mechanisms of hyper HDL-cholesterolemia in diabetics treated with insulin. The serum HDL-cholesterol levels of diabetics treated with insulin were significantly higher and the serum triglyceride levels of female diabetics treated with insulin were significantly lower than those of the other groups (diabetics treated with oral agents, diet alone and controls).
However, the serum LCAT activity of diabetics treated with insulin was not significantly different from that of other groups.
The important role of hyper HDL-cholesterolemia in diabetics treated with insulin may be due not to serum LCAT activity, but rather to enhanced serum LPL activity by exogenous insulin.
