Abstract
Sixty-four newborn Chinese hamsters were divided into three groups. Group A received injection of monosodium glutamate (MSG) at a dose of 4 mg per g of body weight during 3 days after birth, and was fed the standard diet containing 0 1% synthetic trypsin inhibitor, N, N-dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)-phenylacetatej methansulfonate. Group B received 3 days injection of MSG, and was fed the standard diet. Group C received saline injection and was fed the standard diet. The mean plasma glucose level in group B was significantly high compared to that in group C at the 11th week. A slight significant difference was noted between groups A and C. Hyperglycemia of over 160 mg/dl was seen in 5.6% of group A, 44.4% of group B and 0% of group C at the 7th week. At the 11th week, hyperglycemia of over 300 mg/dl was observed in 63.0% of group B, but none was noted in groups A and C. These results suggest that the synthetic trypsin inhibitor may suppress MSG-induced hyperglycemia in newborn Chinese hamsters.
