Abstract
The present study was undertaken to compare sensitivities to antilipolytic action of insulin of weight-matched two groups, 43 diabetic patients and 43 healthy control subjects. The sensitivity was estimated by the ratio of decrement of serum FFA (ΔFFA) to increment of serum IRI (ΔIRI) during the first 60 min-period of 100 g OGTT. The ΔFFA was not dependent upon age but there was a negative correlation (r=-0.25) between the decrement of FFA and the degree of obesity. The ΔFFA in diabetics (422.5±257.1μEq/l)(M±SD) was not significantly different from that of the control subjects (429.7±269.5μEq/l).
Since ΔFFA was revealed to be dependent upon the fasting FFA level (F-FFA), a new parameter, ΔFFA/F-FFA was calculated as “corrected decrement of FFA”. This value in diabetics was 0.78±0.41, which was significantly lower than that of the control subjects (1.12±0.51).ΔIRI in diabetics (78.0±48.7μU/ml) was remarkably less than that of the healthy subjects (272.4±137.9 μU/ml). The sensitivity index, ΔFFA/F-FFA/ΔIRI in diabetics was 16.49×10-3, which was highly significantly greater than that of the control group (4.84×10-3).
These results strongly suggest that the sensitivity to anti-lipolytic action of endogenous insulin was enhanced in diabetic patients irrespective of obesity.
