Abstract
Recently, it has been found that the HbAI level tends to be high in renal failure without diabetes. In the present study, we investigated whether HbAI could be used as an indicator of control in patients with renal failure as well as in diabetic patients.
The correlations between HbAI and BUN, or serum creatinine for a duration of 8 weeks prior to blood collection were investigated. The best correlation was found between HbAI and BUN, or serum creatinine also at 1 to 2 weeks before blood collection. It was found that a better correlation existed between HbAI and BUN (r=0.59, n=32, p<0.001) than between HbAI and serum creatinine (r=0.42, n=31, p<0.02) at 1 to 2 weeks before.
It appeared, therefore, that HbAI was produced by carbamylation of urea, and HbAI could be used as an indicator of the state of renal failure of 1 to 2 weeks before in patients with renal failure without impaired glucose tolerance.
