1983 Volume 26 Issue 8 Pages 879-884
We examined the pancreatic islet cell antibodies (I.C.A.) in one population in Japan. The incidence of I.C.A.was 6 cases out of 1, 125 subjects, or 0.5%.The incidence of I.C.A.in males was 0.6% and that in feamles was 0.5%.All the cases with I.C.A.suffered from neither type 1 nor type 2 diabetes.However, one case had diffuse goiter and antithyroid antibodies, and another case had antinuclear antibodies.The case with diffuse goiter and circulating thyroid antibodies was suspected to suffer from Hashimoto's thyroiditis.The other 5 cases with I.C.A.had no autoimmune endocrinopathies.
There were 13 cases with overt diabetes in the population, 2 of whom were of the insulin dependent type and 11 were of non-insulin dependent types.However, none of them had I.C.A.
The titers of I.C.A. ranged from 1: 5 dilutions to 1: 10 dilutions.The titer in the case with Hashimoto's thyroiditis was the highest of all.The I.C.A.in 6 cases showed diffuse cytoplasmic fluorescence over the pancreatic islet cells, and these were so-called “classical” patterns.
Identical tests for I.C.A.were performed on childhood diabetics as type 1 diabetics.The incidence of I.C.A.in 80 cases with type 1 diabetes was 36.3%.
