Abstract
In order to evaluate the in vivo effects of different insulin regimens, a glucose infusion test was performed for 24 hours on 23 diabetics; 10 cases were treated with continuous subcutaneous insulin infusion (CSII group), 5 cases with subcutaneous injection of intermediate-acting insulin in the morning (INT group), 5 cases with a mixture of intermedite-and short-acting insulin in the morning (Mix-I group) and 3 cases with a mixture of intermediate-and short-acting insulin in the morning and a mixture of long-and short-acting insulin in the evening (Mix-II group). Insulin effect was expressed in terms of metabolic clearance rate of glucose (MCRG).
In the CSII group, a rather sharp peak of MCRG was detected at 90 minutes after bolus injection.
Accumulated whole day MCRGs in the CSII group, INT group, Mix-I group and Mix-II group were 126.8±50.5, 64.1±27.1, 125.8±38.9 and 136.3±9.5ml/kg/min, respectively. Ratios of MCRG from the morning until midnight to those from midnight until the next morning in the 4 groups were 6.7, 3.9, 6.1 and 5.3, respectively.
In the CSII group, MCRG from 6: 00 to 7: 00 was 80.2% of that from 3: 00 to 4: 00, which was higher than those in INT group (68.4%), Mix-I group (72.0%) and Mix-II group (76.6%).
These results indicate that CSII supplies enough insulin in the daytime and morning, but not such an excessive level of insulin in the middle of the night compared with other insulin regimens.
