Abstract
To clarify the relationship between diabetic urinary bladder dysfunction (DUBD) and subjective symptoms related to DUBD, and also between DUBD and coefficient variation of R-R interval in ECG (CVR-R), cystometry was carried out in 54 diabetics ranging in age from 29 to 65 years. The criteria for DUBD in this study were based on the result of cystometry in 8 healthy subjects.
Frequency of residual urine (RU), and abnormalities in first desire to void volume (FDVV) and maximum desire to void volume (MDVV) were 31.5, 61.1 and 72.2%, respectively. The prevalence of patients with one of these abnormalities was 81.1%. The cystometrograms of all of the dibetics with DUBD showed underactive detrusor function and detrusor areflexia. High incidence of DUBD was recognized even in patients without subjective symptoms and/or with a slight degree of symptoms related to DUBD. There were high incidence of RU and abnormal MDVV in diabetics with advanced retinopathy, proteinuria and orthostatic hypotension. CVR-R of diabetics with RU was higher (p<0.001) than that of patients without RU. CVR_R was negatively correlated to both FDVV (r=-0.56) and MDVV (r=-0.62).
From these results, it is possible to conclude that there was a high prevalence of DUBD even in patients without subjective symptoms, and that complication with DUBD can be suspected by a decrease in CVR-R without the patient having to undergo cystometry.
