Abstract
The influence of insulin on cardiac function was studied in 35 patients with old anterior myocardial infarction. RI angiocardiography was used to determine the global ejection fraction (GEF), infarcted regional ejection fraction (IEF), non-infarcted ejection fraction (NEF) and enddiastolic volume (EDV). The 75g oral glucose tolerance test (OGTT) was performed to obtainΣBS and ΣIRI.
The results were as follows: 1.ΣBS and ΣBS/ΣIRI had no significant correlation with GEF, NEF, IEF or EDV.
2.ΣIRI correlated well with GEF, NEF, IEF and EDV:
GEF=-41.4×(logΣIRI) 2+440.6×logΣIRI-1124.6 (p<0.01)
NEF=-42.5×(logΣIRI) 2+448.3×logΣIRI-1122.3 (p<0.01)
IEF=-33.4×(logΣIRI) 2+356.0×logΣIRI-914.2 (p<0.01)
EDV=89.3×(logΣIRI) 2-950.0×logΣIRI+2623 (p<0.01)
3. The highest value of GEF, NEF and IEF with the lowest value of EDV was observed whenΣIRIwas in the area of 200μU/ml.
These results suggest that insulin has a protective effect on the myocardium when insulin response to 75g OGTT is in the normal range.
