Abstract
A 47-year-old male patients was studied since his first admission due to diabetic ketoacidoticcoma at the age of 40. He achieved his first remission one month later as a result of intensive insulin treatment, such as the use of an artificial pancreas, CSII and multiple insulin injection.
During this 7-year follow-up period, he experienced another two exacerbations of diabetes mellitus. ICSA was found to have become positive on the second and third admissions, but ICA and other autoantibodies remained negative. Also, there were no significant changes in the titers of antibody to various viruses.
He again entered into his second and third remissions within a relatively shorter period, by intensive treatment with insulin. His ICSA was again found to be negative on both occasions.
There was no clinically apparent microangiopathy after 7 years, although he showed impaired glucose tolerance during each remission period as indicated in sequential OGTTs.
This is the first case report in the world, as far as we have investigated, of such a patient successfully introduced into third remission.
