Abstract
Recent studies have demonstrated that triphenyltin compounds, widely used as agricultural chemicals and a marine antifoulant, induce diabetes in rabbits and hamsters. The present experiments were conducted to elucidate the mechanisms of the inhibition of insulin release from the hamster pancreatic islets by triphenyltin chloride (TPTC1). The oral administration of TPTC1 (60 mg/kg body weight) to hamsters inhibited the release of insulin from the isolated islets in response to 200 or 500mg/dl glucose (p<O.01) or 10-7 M 4β-phorbol 12β-myristate 13α-acetate (PMA)(p<0.05). The exposure to TPTC1, diphenyltin dichloride or phenyltin trichloride in vitro had no effect on the release of insulin from the isolated islets in response to 500 mg/dl of glucose.
These results suggest that diabetes induced in hamster by TPTC1 is due to inhibition of insulin release from pancreatic islets. Since insulin release was not affected by addition of TPTC1 and other phenyltins in vitro, some metabolites of these compounds seem to be related to the inhibition of insulin release from pancreatic islets.
