Abstract
Insulin treated diabetic in-patients under caloric restriction (about 25 to 30 keal/kg standaid body weight/day) and 30 to 60 minutes of walking daily were divided into the three groups of non insulin dependent diabetics (NIDDM, n=21), NIDDM with chronic hepatitis (DM with CH, n=8) and insulin dependent diabetics (IDDM, n=7). 24 hour urinary C-peptide excretion (24 h U-CPR, μg/day) was 48±6 (mean±SEM) in NIDDM, 75±8 in DM with CH and ≤5.0 in all IDDM. Under 140mg/dl of fasting blood glucose, insulin dosage (U/kg body weight/day) was 0.36±0.03 in NIDDM, 0.43±0.05 in DM with CH and 0.51±0.04 in IDDM. CH, especially alcoholic CH, seemed to be a cause to an increase of insulin requirement in diabetic patients.
There was a good negative correlation between insulin dosage and 24 h U-CPR (r=-0.718, p<0.0005), fasting serum C-peptide (r=0.692, p<0.01) or 2 hour postprandial serum C-peptide (r=-0.532, p<0.025).
These results indicate that 24 h U-CPR and fasting or postprandial serum C-peptide are good and convenient parameters to assume the suitable insulin dosage in diabetic patients.
