Journal of the Japan Diabetes Society
Online ISSN : 1881-588X
Print ISSN : 0021-437X
ISSN-L : 0021-437X
Metabolic, Hormonal and Sympathetic Responses to Exercise in Patients with Non-insulin-dependent Diabetes Mellitus
Relation to Fasting Level of Serum Ketone Bodies
Takashi OhoshiJoji IinumaSusumu NishimuraKishio NanjoKazuhiro IwoKei Miyamura
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Keywords: NIDDM
JOURNAL FREE ACCESS

1988 Volume 31 Issue 11 Pages 835-842

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Abstract
Metabolic, hormonal and sympathetic responses to exercise (1watt/kg ideal body weight, 20 minutes) were investigated in patients with non-insulin-dependent diabetes mellitus (NIDDM) and normal subjects after overnight fasting. The NIDDM patients had no proliferative retinopathy, renal dysfunction, or decreased heart-rate variation.
In the whole NIDDM group (n=16), there was a positive correlation between serum 3-hydroxybutyrate (3-OHBA) concentrations at rest (“0 min”) and urinary catecholamine responses to exercise (ΔNA: r=0.70, p<0.01, ΔAdr: r=0.70, p<0.01). In both NIDDM subgroups (group (H): 3-OHBA≥70μM/l at 0 min, n=8, group (L): 3-OHBA<70μM/l at 0 min, n=8), plasma glucose (PG) was decreased after exercise. 3-OHBA was greatly decreased at cessation of exercise (“20 min”) in group (H). Serum IRI was decreased at 20 min in group (L) and serum HGH was increased at 20 min in both groups. Catecholamine responses were increased in group (H). In the normal subjects (group (N): n=5), there were no significant changes.
Sympathetic hypersensitivity to exercise has already been observed in NIDDM patients with fasting hyperketonemia, before metabolic and hormonal responses to exercise become exaggerated.
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