Abstract
To elucidate the relationship between the 24-hr urinary excretion rate of fibronectin degradation products (24-hr U-FnDP) and intraglomerular thrombin generation in diabetic nephropathy, 24-hr U-FnDP, 24-hr urinary protein (24-hr U-), and the renal venoarterial difference in soluble fibrin monomer complexes (V-A·SFMC) were determined in 16 iabetic patients. Moreover, renal biopsy was performed in 7 diabetics with various degrees of 24-hr U-P to clarify the interaction of 24-hr U-FnDP with diffuse diabetic glomerular lesions.
V-A·ESFMC was elevated roportionally (r=0.84, p<0.001) to the increase in 24-hr U-FnDP. 24-hr U-P also correlated positively (r=0.69, p<0.005) with V-A·SFMC. The progression of diffuse diabetic glomerular lesions was closely related to the ncrease in 24-hr U-FnDP and 24-hr U-P.
It was concluded that 24-hr U-FnDP as well as 24-hr U-P might reflect the degree of intraglomerular thrombin generation and extent of diffuse diabetic glomerular lesions, while 24-hr U-FnDP would e a more suitable parameter of the development of diabetic nephropathy, because it has been reported that 24-hr U-FnDP is derived from glomeruli.
