Statistical Analysis of HLA-types of 26 Patients with Insulin Autoimmune Syndrome Reported in Japan

Abstract

Insulin autoimmune syndrom (IAS) is one of the causes of spontaneous hypoglycemia in Japan. Although the HLA-types were reported in 26 patients in Japan during 1970 to 1988, there has been no statistical analysis of HLA-types in IAS. In this study the results of that determination of HLA-type were gathered and compared with HLA-types of the general Japanese population. In the patients with IAS, the frequency of each of HLA-A 11, B 15 (Bw 62), CW 4 and DR 4 was much higher than that of each correspondent type in the general population, and an especially significant difference was detected in the inside of BW 62, CW 4 and DR 4. The remarkably high frequency of B 15 (BW 62), CW 4 and in DR 4 in IAS was not related to the use of drugs containing a SH group which might provoke IAS, nor to the age of onset of IAS. In conclusion, patients with IAS in Japan had some specific types of HLA-antigens associated with susceptibility this syndrome.