Abstract
To investigate the factors affecting residual B-cell function of IDDM patients, we examined correlation of the maximum minus the minimum value of serum C-peptide immunoreactivity (ACPMmax) during the 50 g OGTT as residual pancreatic B-cell function and various clinical indices in 32 IDDM patients with an age of onset of 17.4+0.9 (Mean±SE) years and duration of disease of 3.4±0.4 years. The clinical indices used for analysis were sex, family history of diabetes, HLA DR type, age at onset, duration, presence of ICA, mode of onset, history of obesity, seasonality of onset and glycemic control. Th variables selected by stepwise method were 1) seasonality, 2) age at onset, 3) presence of ICA, 4) presence of HLA DR4, and 5) family history. The established regression model, which was significant, was as follows: structure ΔCPRmax =-0.07-0.46 (seasonality) +0.04 (age at onset)-0.42 (presence of ICA) +0.35 (presence of HLA DR4)-0.44 (family history). The data suggest that these clinical indices must be taken into consideration in determining the extent of destruction of pancreatic B-cells of patients and the etiology of IDDM.
