Abstract
To investigate factors affecting serum immunoreactive trypsin concentration (IRT), we examined the correlation IRT and various clinical indices in 42 IDDM patients with an age of onset of 16.5±0.8 (Mean±SE) years and duration of disease of 6.8±0.8 years. The indices used for analysis were sex, age at onset, duration, family history of diabetes, mode of onset, season of onset, history of obesity, percentage ideal body weight, pancreatic B-cell function, presence of ICA, HLA DR type, serum creatinine concentration, and glycemic control. The variables selected by the stepwise method were 1) HLA DR9, 2) serum creatinine concentration, 3) presence of ICA, 4) sex, and 5) age at onset. The regression model established, which was significant, was as follows: structure log (IRT) =4.00-0.39 (presence of HLA DR9) +1.51 (serum creatinine concentration)-0.33 (presence of ICA) +0.33 (female)-0.02 (age at onset). Serum IRT reflects pancreatic exocrine function, hence the data suggest that these clinical indices must be taken into consideration in determining the cause of the decline in pancreatic exocrine function.
