Abstract
A 34-year-old woman with insulin-dependent diabetes mellitus (IDDM) was admitted to our hospital for glycemic control before bilateral cataract surgery. Glycemic control deteriorated during the luteal phase and just before menstruation during the 3-month period of continued strict diet therapy and CSII treatment.
Insulin sensitivity was assessed using the euglycemic clamp technique during the menstrual cycle. The glucose infusion rate (GIR) was lower in the luteal phase than in the menstrual or the follicular phases. Insulin resistance in the luteal phase was accompanied by elevated serum progesterone concentrations.
These findings suggest that changes in insulin sensitivity due to the menstrual cycle are one of the factors adversely affecting blood glucose control in women with IDDM.
