1992 Volume 35 Issue 9 Pages 761-766
We investigated the interrelationship between blood pressure and glucose tolerance in 6250 subjects from the Multiphasic Health Testing and Service Section of Kampo Medical Center. All subjects underwent a standard 75 g oral glucose tolerance test. Blood pressure was measured and classified into groups based on WHO criteria. Plasma IRI was measured in 576 subjects.
The prevalence of diabetes mellitus in the hypertensive group was 18.4%, significantly higher than the 7.4% in the normal group. The 1-hour postload plasma glucose, and 2-hour plasma glucose levels in the hypertensive group were significantly higher than those of the normal group in both obese and non-obese subjects.
The fasting plasma IRI concentration correlated significantly with both systolic and diastolic blood pressure in subjects with normal glucose tolerance. The fasting plasma IRI levels were significantly higher in the hypertensive group than in the normal group in both obese and non-obese subjects. Furthermore, in subjects with normal glucose tolerance, the fasting plasma IRI concentration was also significantly higher in the hypertensive group than in the normotensive group.
These results suggest that insulin resistance which expresses itself as compensatory hyperinsulinemia may be the common factor in pathogenetic interactions between high blood pressure and glucose intolerance, independent of obesity.
