Abstract
The relationship between asymptomatic lacunes detected on MRI to micro-and macroangiopathy in diabetics is poorly understood. Asymptomatic patients in a multiple lacune (ML) group (57 cases) were studied in comparison with a lacune-free group (53 cases). Explanatory variables are duration of diabetes mellitus, CHO, TG, HDL-C, LDL-C, atherogenic index (AI), LP (a), retinopathy, neuropathy, nephropathy, CHD, ASO, hypertension, blood sugar control and treatment. Both groups were then divided to younger (≤64) and older (≥65) patients, and reanalyzed in the same manner. Based on the results of univariate analysis, age, hypertension, and neuropathy were associated with ML. Multivariate analysis showed age to be an independent predictor of ML. In younger patients, a combination of 4 factors: retinopathy, hypertension, BMI and Al yielded the most significant association with ML. Among older patients, no combinations of variables led to any significant association with ML. In conclusion, ML was associated with aging, and in the middle-aged group it was associated with microangiopathy and hypertension.
