Abstract
The cross-correlation coefficients of glycated albumin (GA) and hemoglobin (GHb) with the plasma glucose level in the preceding period were analyzed theoretically by introducing random fluctuation into daily plasma glucose variation. Computer simulation showed that GA and GHb adequately represented slow plasma glucose fluctuation in stable diabetic patients, but did not reflect rapid plasma glucose fluctuation in unstable diabetic patients. The cross correlation coefficients of GA and GHb with the previous plasma glucose level in stable diabetic patients were maximal for the plasma glucose levels 10-15 and 20-40 days before, respectively, whereas those in unstable diabetic patients showed a maximum for the plasma glucose level just a few days before. These results suggest that the cross-correlation coefficient depends strongly on plasma glucose stability in diabetic patients and that plasma glucose stability should be taken into consideration in analyzing cross-correlations between glycated proteins and the plasma glucose level in the preceding period.
