1995 Volume 38 Issue 5 Pages 375-382
To clarify whether angiotensin-converting enzyme inhibitor (ACEI) prevents the development of nephropathy in streptozotocin (STZ)-induced diabetes in spontaneously hypertensive rats (SHR), changes in creatinine clearance (Ccr) and urinary albumin excretion rate (UAE) were observed for 4 weeks. At the end of the experiment the numbers of anionic sites (AS) on the lamina rara externa of the glomerular basement membrane (GBM) were evaluated in the following five groups:(1) control SHR, (2) ACEI-treated SHR (SHR-ACEI), (3) STZ-induced diabetic SHR (SHR-STZ), ACEI-treated (week 1 to 4) STZ-induced diabetic SHR (SHR-STZ-ACEI), (5) ACEI-treated (week 3 to 4) STZ-induced diabetic SHR (SHR-STZ-late ACEI). Elevation of Cc, -was found to have been suppressed in SHR-STZ-ACEI when compared with SHR-STZ. The increase in UAE in the SHR-STZ was also suppressed in the two ACEI-treated diabetic SHR groups, and the decrease in number of AS in the SHR-STZ was prevented in the two ACEI-treated diabetic SHR groups.
From these results, ACEI appears to prevent the development of nephropathy in STZ-induced diabetic SHR by suppressing the increase in blood pressure and mitigating the increase in permeability of the GBM.
