Lipid Abnormalities of Erythrocyte Membranes in Diabetic Patients

Analysis of Lipid Peroxide in Erythrocyte Membranes and Antioxidant Effect of Nilvadipine to Lipid Peroxidation

Abstract

Significantly elevated levels of 7-keto cholestadiene (KD) and significantly reduced levels of poly-unsaturated fatty acids (linolic acid, arachidonic acid and docosahexaenoic acid) were found in the lipid fractions of diabetic erythrocyte membranes when compared with controls. These alterations suggest that there is significant oxidative stress in diabetes. In particular, the levels of KD were correlated to the values of HbAic. Cholesta-3, 5-diene (Die) peroxidation stimulated by ultraviolet-B irradiation generating free radicals was found to produce KD. The inhibitory effect of a Ca anatagonist, nilvadipine, on Die peroxidation by UV-B irradiation was studied. Nilvadipine inhibited the peroxidation of Die to KD and was considered to be an antioxidant of lipid peroxidation. Nilvadipine was thought to be useful in the treatment of diabetes with hypertension.