Abstract
To determine the clinical significance of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in hemodialysis patients, we measured levels of these peptides before and after hemodialysis, and examined their correlation with clinical and cardiac parameters in diabetic (DM) and non-diabetic (non-DM) groups. The results were as follows:(1) The change in ANP level correlated significantly with the change in body weight, but the change in BNP level did not correlate with it in either group.(2) The BNP level was significantly higher in the DM group than in the non-DM group, and correlated significantly with the QTc interval in the DM group. It is necessary to measure and evaluate not only ANP, which is a parameter of volume overload, but also BNP, which is a parameter of ventricular overload, in diabetic patients on hemodialysis.
