Abstract
The measurement of urinary albumin (U-Alb) is considered essential for the early diagnosis of early stages of diabetic nephropathy, with microalbuminuria defined as an albumin excretion index of greater than 30 mg/g creatinine and less than 300 mg/g creatinine. This report examines the urinary glycated albumin/serum glycated albumin (GA ratio) as a measure of the threshold for the onset of diabetic nephropathy.
The GA ratio was 2.099±0.300 in 11 subjects (age 61.5±3.5 years) in the healthy control group, 2.097±0.577 in 14 subjects (age 60.4±3.6 years) in the normoalbuminuria group, 1.271±0.394 in 15 subjects (age 59.1±9.7 years) in the microalbuminuria group (Micro group), and 0.950±0.075 in 13 subjects (age 60.5±11.8 years) in the macroalbuminuria group (Macro group).
The GA ratio decreased from approximately 2.000 in the Normo group to a cluster at 1.000 in the Macro group. The point of intersection between the distribution line of a GA ratio of about 1.000 and the regression curve for the GA ratio determined by the polynomial method corresponded to an albumin excretion index of about 150 mg/g. creatinine.
