Abstract
A 70-year-old woman was diagnosed as having NIDDM in 1989. She had been treated with glibenclamide (2.5mg/day) with poor glycemic control (in February 1996: HbA1c 10.7%). Even after admission to our hospital with strict dietary control and continuous glibenclamide (2.5mg/day), her plasma glucose level did not fall significantly. She was given voglibose (0.6mg/day) in addition to glibenclamide. Three days after administration of voglibose, the plasma glucose level decreased to 59 mg/dl. She stopped taking glibenclamide and voglibose. However, the blood glucose level continued to decrease (at its nadir: blood glucose 52 mg/dl, IRI 16.51μU/ml, CPR 5.5 ng/ml). There was no evidence of insulinoma.
In this case, hypoglycemia developed after the use of voglibose on top of glibenclamide, so that it is likely that voglibose is, at least in part, responsible for the development of prolonged hypoglycemia.
