Abstract
We report a case of insulin autoimune syndrome (IAS) repeatedly induced by thiamazole (MMI). A 26-year-old man was referred to our hospital because of hypoglycemia in 1994. He was found to have hyperthyroidism at his first clinic visit in 1988. In 1991, he was prescribed thiamazole at another clinic. Three weeks later, he had a hypoglycemic attack. After changing MMI to propylth iouracil (PTU), he had no more hypoglycemic attacks. In 1994, he came for his third-clinic visit and received MMI again. Four weeks later, he had a hypoglycemic attack again. On his fourth visit, he was admitted to the fourth hospital because of the hypoglycemic attack. In the hospital, he was medicated with MMI continuously, and he had a hypoglycemic attack yet again. He was transfered to our hospital to examine the causes of hypoglycemia. Detailed past history of the present illness revealed that the present case is IAS repeatedly induced by MMI.
