1999 Volume 42 Issue 10 Pages 837-842
The treatment associated with renal transplantation frequently causes diabetes mellitus (DM) in recipients with no previous evidence of underlying DM. However only limited data have been reported on postrenal transplant DM (PT-DM) which develops more than 6 months after renal transplantation. We retrospectively studied 60 recipients who under went transplantation between January 1972 and March 1996, and evaluated the prevalence rate and the predisposing factors for PT-DM as of September 1996.
Among these cases, 12 patients developed PT-DM during the observation period of 5.0±3.6 years, while the other 48 patients did not. Between the two groups, with and without DM, there were no significant differences in the types and the total doses of immunosuppressive agents used after renal transplantation. The mean ages were significantly older in the PT-DM group than in the PT-NonDM group (47.5±10.3 years vs 39.0±8.6 years, P<0.005).
The prevalence of PT-DM was greater in patients aged 40 years or more than in those less than 40 years (30.3% vs 7.4%, respectively), and highest in those aged 40 years or more who had a family member with DM (62.5%).
Our data suggest that after renal transplantation those recipients with a family history of DM are more susceptible to develop DM in association with aging.
