Changes of Serum CEA Correlated with Glycemic Control in a Case of Rectal Cancer Complicated with Type 2 Diabetes Mellitus
1999 Volume 42 Issue 10 Pages 847-851
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1999 Volume 42 Issue 10 Pages 847-851
A 62-year-old man was diagnosed with type 2 diabetes mellitus at the age of 42, and oral hypoglycemic agents were administered since the age of 50. He was diagnosed as having rectal cancer in June 1994, and a proctectomy was performed, but local recurrence was detected at the closed anal region in January 1996. At that time, his serum carcinoembryonic antigen (CEA) level began to rise with concomitant worsening of his glycemic control. After institution of insulin therapy in July 1997, his HbA1c decreased from 15.9% to 10.6%, and his serum CEA level also rapidly decreased from 273.0ng/ml to 94.1ng/ml. A similar decrease in his serum CEA level with improvement of HbA1c was again observed on a subsequent admission in August 1998. Correlation between serum CEA and HbA1c was highly significant (r=0.884, p<0.0001). We conclude that hyperglycemia promoted CEA production due to rectal cancer in this case.
