Analysis of Urinary Excretion of Type IV Collagen as a Predictor of Progression of Early Diabetic Nephropathy
Two-year Follow-up Study
1999 Volume 42 Issue 10 Pages 859-862
Details
1999 Volume 42 Issue 10 Pages 859-862
To determine whether urinary excretion of type IV collagen can be used as a predictor of progression of early diabetic nephropathy, we measured the levels of type IV collagen and albumin in first-voided morning urine samples from 190 non-insulin dependent diabetic patients with normoalbuminuria (urinary albumin creatinine ratio [ACR]<20mg/gCr). Even in these patients, 66.3% showed elevated urinary type IV collagen (urinary type IV collagen creatinine ratio [IV-C]≥3.5μg/gCr). In patients with elevated IV-C, there were significantly more whose ACR after 2 years rose to more than 20 mg/gCr than those whose IV-C remained normal (odds ratio 2.66, 95% confidence interval 1.10-6.43). These results suggest that urinary excretion of type IV collagen might be a useful predictive marker for the progression of early diabetic nephropathy.
