Abstract
In order to clarify the renoprotective effect of angiotensin converting-enzyme inhibitor (ACE-I) in diabetic glomerulosclerosis, the degree of glomerulosclerosis in non-insulin-dependent diabetic model rats, male Otsuka Long-Evans Tokushima Fatty rats (OLETF), were evaluated in a semi-quantitative manner. The administration of temocapril (TP group) in tap water, was started at 26 weeks of age and was continued for another 26 weeks. The administration of temocapril (TP) improved hyperglycemia and prevented hypertension. Proteinuria was remarkable at the age of 26 weeks and increased with time in both the control and TP groups However, proteinuria in the TP-treated group was significantly lower than in the control group. The mean of indices of glomerular sclerosis in the TP group was significantly less than that of the control group.
Several mechanisms, such as improvement of glucose metabolism and prevention of hypertension or other local effects on vascular tone, may participate in the renoprotective effects of ACE-I.
