Clinical Significance of PAI-1 for Lacunar Infarction in Type 2 Diabetic Patients

Abstract

We studied whether plasminogen activator inhibitor 1 (PAI-1) was a risk factor for lacunar infarction in type 2 diabetic patients. Although PAI-1 was not related to HbA_1c concentrations and advanced glycation endproducts (AGEs) or fasting CPR, it was related significantly to the percent of body fat (%BF), body mass index (BMI) and average blood pressure. PAI-1 was also related to platelet count, fibrinogen level and the number of lacunar infarctions analyzed with brain magnetic resonance imaging (MRI). These results suggest that PAI-1 may be a risk factor for lacunar infarction by activating coagulation and inhibiting fibrinolysis in cerebrovascular lesions in type 2 diabetic patients.