Clinical Significance of the Revised Diagnostic Criterion for Impaired Fasting Glucose in Japanese Subjects

Abstract

Based on the revised diagnostic criterion the prevalence of impaired fasting glucose (IFG) among the 3229 examinees in our screening population increased from 10% to 36%. Although sensitivity for predicting IGT and/or DM increased from 26% to 59% after the revision, only 26% had an abnormal 2 hr-glucose value (G2) among the IFG2 (FPG: 100-109 mg/dl) cases. Among the 1158 cases with normal G2 values, the prevalences of obesity, hypertension, hypertriglyceridemia, and ischemic ECG changes were significantly higher in the 234 isolated IFG2 cases than in the 865 NFG&NGT (FPG<100, G2<140) cases. The prevalences of those coronary risk factors and low HDL-olesterolemia in the isolated IFG2 cases were as high as in the 59 isolated IFG1 (FPG: 110-125mg/dl) cases. Among the cases with normal G2, according to the index of insulin resistance obtained from plasma glucose and IRI levels during 75-g oral glucose load, the 357 isolated IFG2 cases were significantly more resistant to insulin than the 524 NFG&NGT cases (HOMA-R: 2.20 vs 1.77, Matsuda&DeFronzo's ISI: 5.49 vs 6.65, mean, p<0.01).