Insulin Resistance Is Associated with Visceral Subcutaneous Adiposity and Serum Triglyceride in Nonobese Japanese Patients with Type 2 Diabetes Mellitus

Abstract

To determine the relationship between insulin resistance and visceral subcutaneous fat adiposity or serum triglyceride (TG) in nonobese Japanese patients with type 2 diabetes mellitus, we conducted a euglycemic hyperinsulinemic clamp study in 149 patients with type 2 diabetes.Visceral and subcutaneous fat were measured by computed tomography (CT).Glucose infusion rate (GIR;index of insulin sensitivity during the euglycemic hyperinsulinemic clamp study) correlated significantly negatively with visceral (r =-0.254, p<0.01), subcutaneous fat (r=-0.261, p<0.01) or serum TG (r=-0.180, p<0.05).Visceral fat areas correlated significantly positively with serum TG (r 0.299, p< 0.01). These results suggest that visceral subcutaneous fat accumulation and serum TG may contribute to the development of insulin resistance in nonobese Japanese patients with type 2 diabetes mellitus.